Before the release of the popular manga Trigun, Nightow studied social science and then majored in media studies. Nightow became popular in the United States thanks to the US release of Trigun. Trigun, the TV series, had a limited broadcast run in 1998. Nightow also created the characters and story for the Sega/Red Entertainment anime and third-person shooter video game series Gungrave. The author lives in Tokyo, Japan.